2021 NFL DFS Week 16 DraftKings Picks

by Kyle Williams
2021-22 NFL DFS Wild Card Weekend DraftKings Picks

Welcome to the 2021 NFL DFS Week 16 DraftKings Picks!

It's been a rough last couple of weeks before Christmas. Last minute shopping, a brutal sickness, and unbelievable amounts of stress. This time of year is not only magical but extremely stressful.

If you know me and follow my work, last week was just an absolute nightmare. I was extremely sick, coughing, stomach issues, head cold, sweats, chills, just about every sign of Covid that you could think of. Lucky enough, it wasn't Covid.

I just wanted to preach one thing to you all. Be safe and try and stay inside as much as possible. It's a tough world out there and people are getting sick every day. I know four of my friends and my girlfriend that have the same sickness.

Just make sure you stay safe and enjoy the holidays with your loved ones this Christmas! Now let's dive into the 2021 NFL DFS Week 16 DraftKings Picks!

2021 NFL DFS Week 16 DraftKings Picks

Click here for Wisdom of the Crowd NFL DFS projections


Matthew Stafford, $6,700

The Rams come into Minnesota this week on a mission. They play the lowly Vikings that rank 30th in passing yards allowed, 26th in passing touchdowns allowed, and 27 in explosive pass percentage allowed. They are miserable against the pass this season.

Stafford comes into this week having 22 or more points in three of his last four games. The one low game was a 15 point outing. With a 26 implied point total and two high-powered offenses, Stafford is a top priority on this slate.

Jalen Hurts, $6,400

We've seen the Eagles being revitalized in the past few weeks thanks to the impressive play of QB Jalen Hurts. Now, he faces a must-win game as the Eagles hang just a tiebreaker with the Vikings out of the playoffs.

Hurts get to take on a cupcake in his division rivals, the New York Giants. They come in as 10-point favorites with a 25.25 team total against the lowly team from NY. With that said, Hurts comes in seeing near 30+ points in two of his last three games.

The matchup against the NFL's 27th in pressure rate and sack rate while ranking 28th in pass defense DVOA spells wonders for Hurts and company. His high-end rushing upside and dual-threat passing ability make the Eagles' second-year passer an elite option.

Running Backs

Alexander Mattison, $6,800

Dalvin Cook was placed on the Covid list this Thursday, which leaves Mattison on the lead back yet again. With the lead back out, he's been a unit for DraftKings players that have played him.

In three games this season with Cook at the helm, Mattison has seen 30.9 opportunities per game and with those, he parlayed his success into 24.3 DraftKings points per game.

Even with a tough matchup against the Rams, the Vikings should rely plenty on Mattison not only on the ground but through the air.

Michael Carter, $5,200

Carter came off the injury report last week. It was highly anticipated but was fully lackluster as he rushed just eight times for 18 yards. We are going to consider that a one-off. Now, on tap is the Jaguars, and we all know what a disaster that is.

The Jags rank 17th in yards allowed to the RB, 28th in points allowed per game, and 11th in DraftKings points per game allowed to the RB position. They are simply a bad unit of the defensive side of the ball.

Pre-injury, Carter from weeks eight to 10, was averaging 19.33 touches per game. His dual-threat receiving and rushing upside propelled him to have a massive outburst 30 point game.

I love Carter in this spot to return to form.

Ronald Jones, $5,100

If you saw the news this week, you know that Leonard Fournette is done for the regular season. That leaves Ronald Jones as the lead back and frankly, that isn't such a bad thing. Take a look at his games last season as the lead back even with Fournette.

He's no slouch and in this high-powered offense, he will have plenty of opportunities. With the Buccaneers coming in as 10-point favorites with a 26.5 implied team total, vegas is predicting that Jones himself is going to see plenty of work.

I'm trusting him in this spot even against the Panthers. Besides, people forget that Jones averaged 5.1 yards per carry last season which ranked 6th in the NFL.

Justin Jackson, $4,200

This play is all contingent on the back of one Austin Ekeler who hit the covid list this week. With his presence likely absent this weekend, Jackson would spell as the main back. Take a look at what he did with a banged-up Ekeler last weekend.

  • 54% of the snaps
  • 14 total opportunities
  • 99 total yards

He popped off even with Ekeler in the offense. With all that said, Jackson and the Chargers come in with a 28 implied team total and are 10,5-point favorites which also means they are projected to go run-heavy.

Against the Texans who rank 6th worst against the running back allowing 27.2 DraftKings points per game to the position, you can trust Jackson and company in this spot.

Wide Receiver

Cooper Kupp, $9,100

There really isn't much to say with Kupp. He has one game this season with less than double-digit targets, and it was nine targets. He's scored double-digit fantasy points in every single game.

He's the best player in fantasy football and easily the most consistent. A stack with Matthew Stafford and Cooper Kupp gives you a 60-point upside and gives you such a high floor. Play Kupp and stack him up with the Rams and their 26 implied team total.

Diontae Johnson, $7,500

The Steelers come into this game needing a win badly to keep their playoff hopes alive. They are massive underdogs taking on a Kansas City unit that has stepped up in recent weeks.

As 10-point underdogs, the Steelers are projected to be bust through the air trailing against the Chiefs. Johnson comes in against the 28th ranked passing unit that is allowing WR's 34.5 DraftKings points per game, middle of the road.

The Toldeo product has been a force against defenses this season averaging 12 targets per game for 79.1 yards per game. He's a PPR machine this season and should dot up the Chiefs' defense when trailing late.

The third-year product is one of the safest bets on the slate as he has scored double-digit points in all but one game and has scored 14.3 or more in all but two games this season.

Antonio Brown, $4,900

Chris Godwin was ruled out last week and now the fake vaccine card king is back and more needed than ever. Pre-injury, Brown was Tom Brady's favorite target seeing 8.4 targets per game.

Now, the Bucs come in off an embarrassing loss as 10-point favorites with a 26.5 implied team total. Brady and Brown should be connecting on tons of opportunities this weekend.

Without the top option in the offense in Mike Evans and Chris Godwin, a pissed-off Brady will look to dot up Antonio Brown this weekend in droves.

Gabriel Davis, $4,700

Cole Beasley has been ruled out for the Bills Sunday with Covid and Emmanuel Sanders remains highly questionable. Regardless of Sanders status, Gabriel Davis will be the team's WR2 in their matchup.

Over his past two games, he's played 83% and 90% of snaps which has translated to a 17% target share over that time span. Across his last three games, he's seen four touchdowns.

At $4,700, he's a smash play scoring double-digit fantasy points in three consecutive game.

Tight End

Dawson Knox, $5,300

If you watched the first Patriots and Bills game just a few short weeks ago, a few things stuck out. The weather for one and the fact that Allen repeatedly targeted Knox. He dropped several big third-down conversions and looked miserable in a rain and wind storm.

That said, it's going to be sunny in Foxboro this weekend and the Bills come in needing a win if they want to get out from the 7th seed in the AFC. Although the matchup is stingy, I have a gut feeling about Knox this weekend.

Cole Kmet, $3,300

The second-year tight end comes into this game off a major high note. He played his largest amount of snaps on the season and had the most amount of yards he's had in his career.

Over the past four games, Kmet has averaged an outstanding eight targets per game. With such outstanding target share and playing time going up against the 27th ranked passing defense versus the TE, I love Kmet in this spot.

Wisdom of the Crowd NFL DFS projections

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